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  1. Research

    Rapid DNA analysis for automated processing and interpretation of low DNA content samples

    Short tandem repeat (STR) analysis of casework samples with low DNA content include those resulting from the transfer of epithelial cells from the skin to an object (e.g., cells on a water bottle, or brim of a...

    Rosemary S. Turingan, Sameer Vasantgadkar, Luke Palombo, Catherine Hogan, Hua Jiang, Eugene Tan and Richard F. Selden

    Investigative Genetics 2016 7:2

    Published on: 17 March 2016

  2. Research

    Y-chromosome phylogeographic analysis of the Greek-Cypriot population reveals elements consistent with Neolithic and Bronze Age settlements

    The archeological record indicates that the permanent settlement of Cyprus began with pioneering agriculturalists circa 11,000 years before present, (ca. 11,000 y BP). Subsequent colonization events followed, som...

    Konstantinos Voskarides, Stéphane Mazières, Despina Hadjipanagi, Julie Di Cristofaro, Anastasia Ignatiou, Charalambos Stefanou, Roy J. King, Peter A. Underhill, Jacques Chiaroni and Constantinos Deltas

    Investigative Genetics 2016 7:1

    Published on: 11 February 2016

  3. Short report

    Tracing Jomon and Yayoi ancestries in Japan using ALDH2 and JC virus genotype distributions

    According to the dual structure model, the modern Japanese ethnic population consists of a mixture of the Jomon people, who have existed in Japan since at least the New Stone Age, and the Yayoi people, who migrat...

    Daisuke Miyamori, Noboru Ishikawa, Nozomi Idota, Yasuhiro Kakiuchi, Stuart McLean, Tadaichi Kitamura and Hiroshi Ikegaya

    Investigative Genetics 2015 6:14

    Published on: 30 December 2015

  4. Research

    Early modern human dispersal from Africa: genomic evidence for multiple waves of migration

    Anthropological and genetic data agree in indicating the African continent as the main place of origin for anatomically modern humans. However, it is unclear whether early modern humans left Africa through a s...

    Francesca Tassi, Silvia Ghirotto, Massimo Mezzavilla, Sibelle Torres Vilaça, Lisa De Santi and Guido Barbujani

    Investigative Genetics 2015 6:13

    Published on: 6 November 2015

  5. Short report

    ‘Mutiny on the Bounty’: the genetic history of Norfolk Island reveals extreme gender-biased admixture

    The Pacific Oceania region was one of the last regions of the world to be settled via human migration. Here we outline a settlement of this region that has given rise to a uniquely admixed population. The curr...

    Miles C. Benton, Shani Stuart, Claire Bellis, Donia Macartney-Coxson, David Eccles, Joanne E. Curran, Geoff Chambers, John Blangero, Rod A. Lea and Lyn R. Griffiths

    Investigative Genetics 2015 6:11

    Published on: 3 September 2015

    The Erratum to this article has been published in Investigative Genetics 2015 6:12

  6. Short report

    A case of false mother included with 46 autosomal STR markers

    For solving a maternity case, 19 autosomal short tandem repeats (STRs) were amplified using the AmpFℓSTR® SinofilerTM kit and PowerPlex® 16 System. Additional 27 autosomal STR loci were analyzed using two domesti...

    Li Li, Yuan Lin, Yan Liu, Ruxin Zhu, Zhenmin Zhao and Tingzhi Que

    Investigative Genetics 2015 6:9

    Published on: 30 June 2015

  7. Short report

    Evaluating the Y chromosomal STR dating in deep-rooting pedigrees

    Y chromosomal short tandem repeat (STR) has been used in time estimations for single nucleotide polymorphism (SNP) lineages or eminent persons. But to choose which mutation rate and estimation method in the Y ...

    Chuan-Chao Wang and Hui Li

    Investigative Genetics 2015 6:8

    Published on: 28 May 2015

  8. Review

    Detecting individual ancestry in the human genome

    Detecting and quantifying the population substructure present in a sample of individuals are of main interest in the fields of genetic epidemiology, population genetics, and forensics among others. To date, se...

    Andreas Wollstein and Oscar Lao

    Investigative Genetics 2015 6:7

    Published on: 1 May 2015

  9. Review

    Inferring positive selection in humans from genomic data

    Adaptation can be described as an evolutionary process that leads to an adjustment of the phenotypes of a population to their environment. In the classical view, new mutations can introduce novel phenotypic fe...

    Andreas Wollstein and Wolfgang Stephan

    Investigative Genetics 2015 6:5

    Published on: 1 April 2015

  10. Review

    Genome-wide insights into the genetic history of human populations

    Although mtDNA and the non-recombining Y chromosome (NRY) studies continue to provide valuable insights into the genetic history of human populations, recent technical, methodological and computational advance...

    Irina Pugach and Mark Stoneking

    Investigative Genetics 2015 6:6

    Published on: 1 April 2015

  11. Review

    Re-inventing ancient human DNA

    For a long time, the analysis of ancient human DNA represented one of the most controversial disciplines in an already controversial field of research. Scepticism in this field was only matched by the long-las...

    Michael Knapp, Carles Lalueza-Fox and Michael Hofreiter

    Investigative Genetics 2015 6:4

    Published on: 11 March 2015

  12. Research

    Metagenomic analyses of bacteria on human hairs: a qualitative assessment for applications in forensic science

    Mammalian hairs are one of the most ubiquitous types of trace evidence collected in the course of forensic investigations. However, hairs that are naturally shed or that lack roots are problematic substrates f...

    Silvana R Tridico, Dáithí C Murray, Jayne Addison, Kenneth P Kirkbride and Michael Bunce

    Investigative Genetics 2014 5:16

    Published on: 16 December 2014

  13. Research

    Different waves and directions of Neolithic migrations in the Armenian Highland

    The peopling of Europe and the nature of the Neolithic agricultural migration as a primary issue in the modern human colonization of the globe is still widely debated. At present, much uncertainty is associate...

    Anahit Hovhannisyan, Zaruhi Khachatryan, Marc Haber, Peter Hrechdakian, Tatiana Karafet, Pierre Zalloua and Levon Yepiskoposyan

    Investigative Genetics 2014 5:15

    Published on: 30 November 2014

  14. Research

    Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences

    Comparisons of maternally-inherited mitochondrial DNA (mtDNA) and paternally-inherited non-recombining Y chromosome (NRY) variation have provided important insights into the impact of sex-biased processes (suc...

    Sebastian Lippold, Hongyang Xu, Albert Ko, Mingkun Li, Gabriel Renaud, Anne Butthof, Roland Schröder and Mark Stoneking

    Investigative Genetics 2014 5:13

    Published on: 24 September 2014

  15. Research

    Evaluating the impacts of stressors of Pseudomonas syringae pathovar tomato on the effectiveness of multi-locus variable number tandem repeat analysis and multi-locus sequence typing in microbial forensic investigations

    Crops in the USA are vulnerable to natural and criminal threats because of their widespread cultivation and lack of surveillance, and because of implementation of growing practices such as monoculture. To prep...

    Mindy James, Ulrich Melcher and Jacqueline Fletcher

    Investigative Genetics 2014 5:10

    Published on: 7 August 2014

  16. Review

    Validation of high throughput sequencing and microbial forensics applications

    High throughput sequencing (HTS) generates large amounts of high quality sequence data for microbial genomics. The value of HTS for microbial forensics is the speed at which evidence can be collected and the p...

    Bruce Budowle, Nancy D Connell, Anna Bielecka-Oder, Rita R Colwell, Cindi R Corbett, Jacqueline Fletcher, Mats Forsman, Dana R Kadavy, Alemka Markotic, Stephen A Morse, Randall S Murch, Antti Sajantila, Sarah E Schmedes, Krista L Ternus, Stephen D Turner and Samuel Minot

    Investigative Genetics 2014 5:9

    Published on: 30 July 2014

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