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Table 4 Median and 95% Credible Interval (CI) of the estimates of the time when selection started

From: Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing

Gene Population under positive selectiona Time of selection (95% CI) σ (95% CI) h(95% CI)
TYRP1 Europeb 50,250 (13,500 to 97,250) 361.94 (55.6 to 984.79) 1.70 (0.71 to 4.28)
OCA2 Europe,b East Asia 45,875 (12,750 to 95,006) 383.42 (36.07 to 992.04) 2.04 (0.78 to 4.56)
KITLG Europe,b East Asiab 46,000 (11,750 to 93,269) 385.49 (37.68 to 1036.32) 2.01 (0.74 to 4.41)
DCT East Asiab 48,500 (11,250 to 97,006) 789.24 (55.21 to 1584.98) 1.90 (0.67 to 4.11)
SLC45A2 Europeb 27,500 (10,500 to 73,294) 676.53 (127.73 to 1026.06) 1.10 (0.53 to 2.60)
Neutral simulation Europeb 44,875 (12500 to 95,756.25) 593.18 (47.99 to 1086.22) 1.69 (0.56 to 3.97)
  1. aThe table shows the selection parameter σ (defined as 4 × Ne × s, where Ne is the harmonic mean of the effective population size through time) and overdominance parameter h computed for each population that has been suggested as being under selective pressures in the genes that have been sequenced, data from Soejima et al. [30] for SLC45A2, known to be under selective pressure in Europeans (see Methods), and 5 kb produced under a neutral out-of-Africa model (s = 0, h = 0).
  2. aFrom Lao et al. 2007. Prior distributions (without scaling) were truncated normal (mean ± sd 1810 ± 800 generations, range 400 to 4000) for the time of selection, truncated normal (mean ± sd -4 ± 3, range -4 to 2) for s in logit form, and truncated normal (mean ± sd 1 ± 1, range 0.5 to 6) for h. In total, 2,000 simulations were performed for each gene using as a prior distribution of the demographic parameters the median value of the posterior distributions obtained from the 50 loci (see Methods). A burn-in of 1,000 simulations was used.
  3. bPopulation where the selective pressure was simulated.
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