Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing

Table 2 Neutrality-test statistics of each gene in each population.^a

Gene	Population	Tajima's D	Fu and Li's				Fay and Wu's H	Fu's Fs	EWHT^b	GM^c	CM^d	ED^e
			D*	F*	D	F
OCA2	African (YRI)	0.368	0.67	0.67	0.71	0.71	3.16	1.73	0.18	0.08	0.01	0.95
	European (CEU)	1.36	0.75	1.14	0.79	1.21	-1.94	9.23	0.30	0.16	0.05	0.86
	East Asian (CHB)	0.46	0.70	0.73	0.74	0.77	-5.74	6.78	0.47	0.29	0.38	0.48
TYRP1	African (YRI)	-0.99	0.02	-0.39	-0.02	-0.45	-7.76	-3.4	0.10	0.66	0.65	0.08
	European (CEU)	0.45	-0.70	-0.37	0.19	0.34	-5.24	1.30	0.31	0.96	0.89	0.49
	East Asian (CHB)	-1.41	-0.74	-1.15	-0.85	-1.26	-4.91	-5.20	0.23	0.33	0.19	<0.00005
DCT	African (YRI)	-0.83	1.18	0.57	1.28	0.60	-3.54	-0.14	0.18	0.15	<0.005	0.84
	European (CEU)	-0.20	1.16	0.83	1.23	0.87	-3.89	2.30	0.24	0.39	0.16	0.78
	East Asian (CHB)	0.95	1.12	1.25	1.18	1.32	-4.61	3.72	0.54	0.24	0.44	0.74
KITLG	African (YRI)	0.14	0.35	0.33	0.35	0.33	-4.35	-0.28	0.11	0.13	0.17	0.79
	European (CEU)	0.97	1.25	1.36	1.33	1.44	-4.39	6.24	0.39	4.17E-05	<0.01	0.95
	East Asian (CHB)	1.10	0.29	0.68	0.28	0.70	-2.81	5.01	0.32	0.38	0.69	0.69

^aNeutrality-test statistics and combined P values for each population and gene for which a neutrality test distribution could be computed. Combined P values using the approach proposed by [64] were computed using three different neutrality distributions.
^bEwens-Watterson homozygosity test
^cMaximum likelihood model of Gutenkunst et al [44],
^dCosi best fit to the best-fit parameters of Schaffner et al. [45].
^eEncyclopedia of DNA Elements (ENCODE) data from resampled sequences from three different ENCODE regions.

ISSN: 2041-2223